The Leukemia & Lymphoma Society - Fighting Blood Cancers
2 Replies Last post: Jul 22, 2010 10:35 AM by stell  
ekc516   4 posts since
Jun 9, 2010
Currently Being Moderated

Jun 10, 2010 10:48 AM

CML and Pregnancy

I am a 28 year old female, was diagnosed with CML about 6 months ago.  I am so far responding well to Gleevec.  I am also recently married (11 months ago) and my husband and I always dreamed of having children... Has anyone had any experience becoming pregnant after being diagnosed with CML and starting Gleevec, and successfully carrying that pregnancy to term to deliver a healthy infant?  My doctor tells me that it isn't an impossibility, but there isn't a lot of information (because there haven't been a lot of instances) of women becoming pregnant intentionally after a CML diagnosis.  I am being treated at a major cancer hospital and believe I am getting the best care possible.  My doctor says that at my institution they have had one other patient (ever) to become pregnant after a CML diagnosis.  He says he'll need to do more research, but basically the plan seems to be 1) get me through all 3 stages of remission, 2) stop taking Gleevec and see how my body responds, if they think I will be able to tolerate being off of Gleevec for a duration of time, 3) become pregnant, carry to term, deliver, 4) resume Gleevec (and hopefully only have regressed back to the chronic phase).  Has anyone successfully done this?  Or does anyone have an experience where they became pregnant after a CML diagnosis (I don't mean found out they had CML while pregnant, I mean treated CML, then intentionally stopped taking Gleevec to become pregnant, and resumed Gleevec after the pregnancy).  Or does anyone have any insight at all into this???  Thanks so much.

PhilB   352 posts since
Apr 7, 2009
Currently Being Moderated
1. Jun 10, 2010 5:59 AM in response to: ekc516
Re: CML and Pregnancy

Hi ekc,

You'll get more responses to this one if you post on the 'Living with CML' forum (us CMLers don't get out much) so I'd recommend reposting there.

 

The good news is that there are an ever increasing number of 'Gleevec Babies' born to women in exactly your position.  Your onc is quite right that the protocol is to get you into a deep remission first, and that has to be your initial priority.  Once there you have plenty of options, particularly as it looks increasingly like you only have to come off the big G for the duration of the pregnancy and not while you're trying to conceive (the G-related problems that have been observed with pregnancy relate to the effect of G on the developing foetus, not to any damage to eggs (or sperm for men))

 

CML is generally a slow moving disease and you will be closely monitored during pregnancy.  With luck you won't lose that much response over the 9 months (no breastfeeding I'm afraid - you'll need to get back on G asap after the delivery) and you should quickly regain the lost response once you start the drug again.  There are other options such as a maintenance regime of interferon during the pregnancy (but this has unpleasant side effects) or you could look at the possibility of getting into one of the G + interferon trials currently going on where the aim is to take the drugs for 2 years then stop in the hope of a 'cure'.

 

Bottom line is that you are on an increasingly well-trodden path with plenty of options.

 

All the best

 

Phil

stell   23 posts since
Mar 1, 2010
Currently Being Moderated
2. Jul 22, 2010 10:35 AM in response to: ekc516
Re: CML and Pregnancy

Hi! I'm a 36 year old woman with Hairy Cell Leukemia so I can't comment on Gleevec or CML but I was diagnosed while going through IVF treatments and my doctor gave me permission to keep trying so my partner and I now have an 8 month old.  I had to stop breastfeeding much earlier than I wanted to in order to start chemotherapy.  I think it is unclear to everyone how pregnancy interacted with HCL - and I would LOVE to start getting some information b/c if it possible and not risky, I'd love to have another if I reach a durable remission.  Mostly I'm writing to make contact and say I really hope your dream of having a child comes true!  Also if you find any information I'd love to hear about it as some of the blood cancer info might be the same. Good luck reaching remission and congrats on marriage. If the two of you can get through this kind of stress your first year together, you are going to have a very strong marriage!

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