Hi All,
My mom (59) result showed that she was diagnosis with AML M5. We cannot seek treatment in Singapore as the cost is too high .
But there is a two different chemo drugs idarubicin (not available in my home country) , daunorubicin (was available in my country).
Pls give me some advice how different those two chemo drugs and effectiveness?
Pls share your story who diagnosis with AML M5. I need some advice and help.
Thanks,
Aung
Hi Aung,
I'm so sorry to hear about your Mom's diagnosis. I'm not a doctor, but it's my understanding that idarubicin and danorubicin are pretty similar. Combining one or the other with cytarabine is the standard induction chemotherapy in the US for AML. Has she begun treatment yet?
- WBF
Hi WBF,
Thanks for your reply, she didn't start her chemo yet but doctors said no need to start immediately but they'll start after one or two weeks later.
Till now there is no sign and symptoms of AML but her biopsy result show that she was diagnosis with AML.
How abt the chances of remission for AML M5 and prognosis?
Hello Aung - I am very sorry to read about your mother. My 87 year old father has AML M1 but I can not answer your questions about idarubicin and daunorubicin.
I would just like to mention to you that your mother has a better chance at being cured using chemotherapy than someone much older like my father. My father is on the drug Vidaza because more serious chemotherapy treatment would have been too much for his body. My family and I decided on this treatment knowing that he will likely not be completely cured - - we are just following his wishes to keep him alive but as comfortable and normal as possible until such time as he passes on.
I sincerely hope treatment for your mother goes well and I will include you in my prayers. good luck. sincerely, john f.
Aung, I've always had Idarubicin and not Danorubicin, but they are close cousins and work pretty similarly. Both are very common in induction chemo, as they work to get her into remission. They are often combined with Cytarabine, or some other chemo agent. I believe the Ida got me into remission both times I had AML, and Dano should be a good option for her. Both these drugs can be toxic to the heart, so they will monitor her carefully. I took Ida twice, two years apart, and so far, don't show any heart damage. I had M2 not M5, but now days, a lot of experts seem to rely less on those FAB classifications, and more on the specific cytogenetics, like if there are any abnormal chromosomes, which ones, and how they are defective, to determine treatment. But Ida and Dano are very common in induction chemo for many cases of AML, so her plan sounds very standard to me. Hope your mom does well---I'm sorry about her diagnosis, but lots of us here are doing well, so take heart!
Pam
Daunorubicin is what I had with cytarabine for my induction chemo. As many have said the 2 are very similar and used for standard treatment in the US. Mine was M1 though with normal chromosomes. Your doctor will be able to tell you more after they get results of bone marrow test. Hang in there.
I have the same understanding as WBF, that the two drugs are similar. We do usually have two chemos, including one of those, with our first chemo.
I had m1 instead of m5. But your mom has a really good chance of coming through this in great shape. Do the best you can to get her to treatment as soon as you can and help her fight through it.
Blessings
Hi All,
Thanks you so much for your advise and wishes. I wish you all the best and get well.
As my mom was so thin and she always worried about her resistance and side effect of chemo during induction chemo.
We decided to go back and take treatment in our own country (Myanmar/Burma) as she doesn't have medical insurance in Singapore.
When can we know is she is in remission ? and what are the preparation need to be done ? what is the risk during chemo? pls advise.
I'll keep in my heart all your advise and put people who suffer AML in my prayer list.
Thanks,
Aung
Aung,
I was also M5. My first induction was with cytarabine (ara-c) and Danorubicin. After her induction, they'll wait for her counts to come back before they'll check to see if she's in remission. It may take 2-3 weeks. She has a good chance at fighting it so keep her determined to fight. Does she have any other health issues? They'll check her heart to make sure it can handle the chemo. The chemo can be very hard on other organs so they'll keep an eye on that during the chemo through blood tests. Keep us posted.
Take care,
Kelly
The docs will take care of any preparation necessary and let you know what you might want to do at home when she's ready to go there. Here in the States they do bone marrow biopsies on Day 14 and Day 28. I imagine that's what they'll do at home, too. It's [pretty standard. That will be your earliest indications of how she's doing so far as remission goes.
There's little risk during chemo. But getting through chemo isn't all there is. I think these are good questions but her doctors will do a better job of answering them.
Hope all goes well. Please let us know how she's doing.
Blessings
Hi Kelly,
Thanks for your advise. I wish you all the best. My mom doesn't have any health issue as doctor had checked.
She was worried her induction chemo as she was thin but there is no health issue.
Thanks,
Aung
Hi Aung,
It's just going to be important that your Mom tries to keep eating - her taste buds will be affected by the chemo and that will make food taste funny, plus if she's anything like I was, she won't want to eat. They have medications to help with nausea, so I wasn't overly nauseated, but I had no interest in eating whatsoever and had to force myself to eat because I didn't have a lot to lose, either. I'm thinking of her and sending good thoughts her way - hope she breezes through the treatment and achieves remission.
Please keep us posted on how she's doing.
- WBF
When your mom is able to eat, push high-calorie foods at her. Any weight she can pack on will be helpful. I'm sure they'll be monitoring her weight through the process.
Take care,
Kelly
My husband with M5 just started treatment yesterday Danorubicin- Cytarabine combo.
From what I hear this is one of the proven protocols that has been on a market for decades.
I'm sure it will work for your mom!
Take a good care of her!
Hugs and prayers!
Hi All,
Thanks for your advice. Her chemo will start on next week. I'll let you all know and hope she is well during chemo.
Thanks,
Aung