Any Ideas? My oncologist told me last week that I should just plan on adopting because it isn't smart to father children while taking Gleevec and that I have no option of temporarily stopping Gleevec for a few months (while being monitored of course) to try to conceive. After diagnosis, my dr. didn't have a lot of solid answers of whether I was in danger of not having kids, but now he seems almost 100% positive that having a kid while on gleevec is a bad idea. I read every so often of men saying that they had healthy children born after conceiving while taking Gleevec, and I see some doctors online saying that there is not a lot of evidence for or against having kids on Gleevec. Is my doctor worried about birth defects, developmental problems, or something else? I can't find anything. Is he just erring on the side of caution? Is anybody out there trying to have kids right now? It has been almost three years since I was diagnosed at the age of 30, and at the time my oncologist didn't recommend storing sperm if I wanted to have children. Just curious what other people have heard lately. Berkley
Well, I'm 26 and was diagnosed just a few months ago. I was thoroughly warned about the possibility for sterility; my boyfriend and I were kind of embarrassed because of how serious they were when they broached the topic even though it didn't matter to us. They did suggest storing sperm, but I've always known that if I were to have a child it would be through adoption and not artificial insemination, so I didn't bother.
I'm pretty sure that the concern was with infertility and not the possibility of birth defects. As I understand it, many women have borne children with no problems; I can't imagine that it would be more of a problem for the child if the father were the one with CML. That being said, I don't know any more than you do about this, so take my advice/opinion to be worth a grain of salt.
Hi Berkley,
Glivec comes with the standard 'don't father children' warning to keep the lawyers happy. As far as I am aware though there has never been any real evidence found to indicate that it might actually cause a problem and there are increasing numbers of perfectly healthy babies out there born to dads taking Glivec. Where issues exist with women and Glivec these relate to the possible effects of Glivec in the mother's bloodstream on the developing foetus, not to any flaws in the eggs themselves and there is no reason to expect flaws in sperm either.
One word of warning though - you may find the side effects of Glivec a walk in the park compared to the side effects of having a new baby!
Berkley,
There was a poster here, lycono, who was diagnosed June 2008 and he and his wife are now expecting in December. You can read about his journey with all this at http://hatefulblood.blogspot.com/.
If I remember correctly, he consulted with Dr. Druker and was given the clear to go ahead...(don't quote me on this...please double-check his blog...)
Beth
I know of one person who has CML and is on Gleevec and doing great, who is an expecting father in December. I also sat in a room with a very well known Doctor who most of us know by name, and asked that exact question, and for Gleevec that answer was yes. At the time I was going to Sprycel, the jury is out on that drug. But I got it first hand that it was safe.
So, I know I wouldn't have any worries on Gleevec.
Hans in Seattle