I am a 53 year old male that was diagnosed with CML December 2007. I have been on 400MG of Gleevec since that time. The Gleevec seems to be doing it's job with the exception of some very annoying side effects that definitely effect my quality of life. All my blood work has been normal since that time, however the side effects sometimes seem to outweigh the benefit. My doctor has suggested lowering the dosage and or changing to the next generation of the drug (Sprycel). Have any of you experimented with dosages and or changed medication even when the present medication is doing its job simply to eliminate or lesson side effects? My brothers have been tested for a bone marrow transplant and I have a brother that is a perfect match 10 of 10, my doctor said that a bone marrow transplant should be used as a last resort.