We were in on Wednesday for our regular clinic visit, including vincristine and started our 5 day steroid pulse. Both Micah and Seth have had higher ANC's than they normally do. Micah's was only 1700 or so, but Seth's was over 3,000 for the second month in a row. So they uped the boys' mtx by two extra tabs each Wednesday evening. Has anyone else had this happen in their treatments schedules?  I didn't know an ANC of 1600 was really that high, but I guess it is higher than they like it to be. Earlier this summer in July, they both had a really high ANC at one point (like 6,000 or 9,000). At the beginning of 2009, they were both switched from bactrim 3 days a week, to once daily dapsone. They were switched because they had both struggled with low ANC all the time. We would be at 50% or 75% a good portion of the time. Now, 100% doesn't seem to be doing it's job, so that has me a bit concerned. Just wondering if any of you have had this going on.... We have been in LTM since Feb. 2008, and have about 1 year left of LTM.