The Leukemia & Lymphoma Society - Fighting Blood Cancers
1 Replies Last post: Oct 12, 2009 4:56 PM by Wobbles  
rfoles   1 posts since
Oct 11, 2009
Currently Being Moderated

Oct 11, 2009 2:14 PM

Need help with diagnosis....

Family member, Male, 50 yr old recently diag. with possible CLL.

Awaiting FISH results.

WBC 923

HGB 9.6

HCT 30.0

MCV 141.9

PLT 51

RETIC COUNT 1.8 normal

ALK PHOS 201

LDH 288

ZAP 70 B CELL negative

He has spenomegaly and hepatomegaly.

 

Any ideas????

TIA,

R

Wobbles   308 posts since
Apr 3, 2009
Currently Being Moderated
1. Oct 12, 2009 5:14 PM in response to: rfoles
Re: Need help with diagnosis....

I’ve added units and comments. The blood test results come with units and it is important to include them because not every lab uses the same units. It is easy to start comparing apples to oranges without explicitly stating units.

 

               WBC 923 per mm3    … very low

               HGB 9.6 per deciliter … anemia

               HCT 30.0 … low, consistent with anemia found above

               MCV 141.9 femtoliter … very high, anemia classified as macrocytic anemia

               PLT 51 per nanoliter (also Giga/L) … very low

 

Your relative is definitely having problems with his blood system. I am not surprised that they are checking him for CLL even though the usual B-cell CLL often shows up with excess lymphocytes. There are T-cell versions of CLL that sometimes exhibit low lymph counts. His Mean Cell Volume number struck me the most. He has MCV = 141.9 fL which means his red blood cells are more than 50% larger than normal. Perhaps, the spleen is removing the enlarged red blood cells at a rapid rate. This can cause splenomegaly. It can also lead to anemia because the bone marrow cannot keep up with red blood cell replacement. Something is definitely amiss. (And it does not have to be B-CLL. The FISH test on flow cytometry will be very helpful.)

 

I also have macrocytic anemia with my hgb ranging between 8 to 10 g/dL and my MCV around 120 fL. I can alert you to one annoying question that I’ve had to field over the years: do you abuse ethanol? It seems alcoholics are notorious for developing macrocytic anemia. I take proactive stance and tell them to forget that angle of attack.

 

It is early going for your relative.  He may need a bone marrow biopsy for a definitive diagnosis.  I wish him the best of luck.

 

Joe

 

PS What do the Absolute neutrophil and lymphocyte numbers say?

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