Just got the word back and my mutational analysis done at Mayo was negative for mutations. Hoping I can get off this PCR plateau and hoping the negative analysis means my genome is stable.....! I started the increased dosage of Tasigna a week ago. I wonder if it will do anything? Who knows...
The better of two evils, but not 100% satisfying! I can understand how you must feel. In one sense you are relieved you do not have any mutations and that is really good news, but you still have it in your head that you are not responding that well and it is frustrating you. I think you are responding pretty well and over time things will improve. Beyond mutations some drugs just work better in some people than others do so if things don't improve response wise, a switch to Sprycel is still certainly an option. Hopefully these results give you some peace of mind that while you may be responding slower than you like, you don't have something tricky going on.
Thanks for all the comments. Lucky, you hit the nail on the head. The "why" is always hard to figure out. Maybe this dosage increase will do something, or maybe I have an element of being primarily resistant? Who knows, really. I was diagnosed with a pretty high disease burden. WBC, 289,000. My pcr at dx was only 1.1 though, I guess, which I find odd. This might as far as I ever get with response. I've emailed a lot of the pros and they've all given me different responses. Drucker basically said "CCyR is fine with me and I find that responses improve over time". Who knows what my future will be. I never in my life would have predicted getting leukemia at 27, but life is most certainly a gamble I guess. I do pray that I get over this "hump", only time will tell I guess.