The Leukemia & Lymphoma Society - Fighting Blood Cancers
28 Replies Latest reply: Mar 22, 2012 7:19 AM by pammartin RSS

According to this report we shouldn't be taking PPIs and certain other drugs with Gleevec...

hannibellemo Registered Users
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http://www.reuters.com/article/2012/03/16/us-medco-druginteractions-idUSBRE82F05S20120316

 

"The PPI drugs for heartburn and acid reflux were the most likely to alter the effectiveness and toxicity of Gleevec, researchers said. For the lung cancer drug Tarceva, steroids and PPIs were most likely to decrease efficacy, while certain antibiotics were most likely to increase toxicity."

 

I know when I had my liver toxicity with Gleevec I was taking off Prilosec immediately as well when my onc determined it could also have a negative effect on the liver.

 

Since I'm no longer taking Prilosec I wonder if I can give Gleevec another try?

 

Interesting, regardless.

 

Pat

  • Re: According to this report we shouldn't be taking PPIs and certain other drugs with Gleevec...
    Susan61 Registered Users
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    Hi:  I think it would be great if the Gleevec would work for you.  As for the PPI's, I must be different.  When I started on the Gleevec I wanted to die from the heartburn.  I started on NExium right after I went on the Gleevec.  Probably  within a few  weeks. Your supposed to take it on a empty stomach etc.  I take all my pills including Gleevec and Nexium every  morning with a decent breakfast all these years, and my Nexium has been fantastic and no problems with regard to interference with the Gleevec.  I do notice if I am not hungry in the morning, and I just grab some coffee and toast I do not get GERD,but I get Nausea.  I just know what works for me all these years.

    It might be worth the try.  There are so many though who have not been able to handle all the other side effects of the Gleevec.  I just want to see you get something that you can handle well.

    • Re: According to this report we shouldn't be taking PPIs and certain other drugs with Gleevec...
      hannibellemo Registered Users
      Currently Being Moderated

      Hi, Susan,

       

      Other than the liver issue, a big one, I know, G was a walk in the park for me! The only really bothersome side effect was the foot cramps. It's probably just a pipe dream, but it's nice to think about!

       

      Here I am today moaning and groaning about my disappointments and you have been dealing with this so much longer and with hardly a negative word. I take strength from your courage and perseverence - I would venture to say everone on here does.

       

      Take care!

       

      Pat

      • Re: According to this report we shouldn't be taking PPIs and certain other drugs with Gleevec...
        GerryL Registered Users
        Currently Being Moderated

        Hi Pat,

        It could be worth a try to go back to Gleevec if you want. I had issues with my liver storing up the cholesterol medication, which I don't think happens to everyone. I always try to be careful with anything that might impact the liver, including supplements. As for the muscle cramps, can I suggest you try celery seed supplements, works for me most of the time.

      • Re: According to this report we shouldn't be taking PPIs and certain other drugs with Gleevec...
        billronm@roadrunner.com Registered Users
        Currently Being Moderated

        Hi Pat,

           When I was first dx I was on Nexium for barets disease (esophogial damage caused from acid reflux)  a couple years later my doc called and said I can't take it while I was on G. (DUH) so he switched me to protonix which I have to take the rest of my life.  I started getting a lot of utis when I was on G my pcp always had me take OMG I can't remember the name of it! It's the antibiotic you take when exposed to Anthrax.Uggg I hate this brain fog. Anyway after almost 3 years on G my pcp called me and said I couldn't take that while I was on G either. So she just prescribed penicillen after that. But I've been off G 18 months now and I haven't had a uti since I went off G. Oh man I can't remember the name of that antibiotic, now I won't sleep until I remember it! Oh i'm brilliant I just picked up my pill book to see what the name is. What an idiot I am.  I'll let you know when I remember. Anyways I'm on other medications I wonder how long it will take them to figure out I can't take them with a tki either. I was just put on another bp medicine yesterday, I can't wait to see what this one does to me. I was a zombie this morning, I had to cancel a DR. appt. I can't remember which doctor either. I took my bp pill an hour ago I think it's kicking in. I better go to bed before I forget where my bedroom is. Last week I went to make my bed and I was standing there and my mind went blank, I couldn't remember how to make my bed. We used a trundle bed in Fla.

                                                Good Night All,  love Billie

      • Re: According to this report we shouldn't be taking PPIs and certain other drugs with Gleevec...
        Susan61 Registered Users
        Currently Being Moderated

        Hi Pat:  Thank You for the nice response.  I was reading what Gerry wrote, and is it possible you were on something for Chlolesterol that caused the liver functions to go up, and not the Gleevec.  I think it would be worth it to try again.  At least you know the liver rejuvenates itself again.  When I was first diagnosed, and I was on the Interferon and the Ara-C it made my liver functions rise.  Thats how I qualified for the clinical trial for the Gleevec back then. 

        I guess I just look at how there was nothing but Gleevec for me back in 2000, but you will find something that works.

        I do suffer with those darned foot cramps.  I keep forgetting to try the celery seed. 

        Your a strong lady yourself, and with so much more to offer us you will get on track again.

        Right now I need some strength myself.  I am going through Panic Attacks from a lot of other problems not even related to my CML.  Any Ideas are welcome!!

        • Re: According to this report we shouldn't be taking PPIs and certain other drugs with Gleevec...
          Judy2 Registered Users
          Currently Being Moderated

          Hi Susan,

           

          I am sorry you are having panic attacks, they are the worst. One thing that helps me sometimes is if I lie in bed and put my arms over my head so that my arms are facing the wall, not the ceiling. Then take deep slow breaths through your nose. Putting your arms in this postion forces you to breath correctly and this can sometimes reduce the panic. The other thing I find helpful is to vent. Vent on this board, to friends, to a therapist. and if all else feel there are always drugs. Susan, I hope you feel better soon, it is very unlike you to complain. If there is anything I can do to help please let me know.

           

          Hugs,

          Judy

          • Re: According to this report we shouldn't be taking PPIs and certain other drugs with Gleevec...
            Susan61 Registered Users
            Currently Being Moderated

            Thanks Judy:  I try not to talk about things other than CML, but like I say we live with other problems as well.  Sometimes the other problems can make living with CML harder.  Just so everyone knows its not because of  my CML, its just struggling through with so many other things that I deal with on a daily basis.  Finances, insurance costs. I am trying to help out other family members with issues.  It just all piles up on me, and I guess thats how my body and mind handle it all.  I will suvive it, and I am very open to any suggestions.  I know I am not the only one who has or has had this problem.  It only started about 2 years ago, and I have had CML for 13.years. 

            My husband has had cutbacks on the job, just like  many others.  This has just been a real bad week for me.  My Arthritis has been brutal.  I have it all over, especially in my neck and back and legs.  So I guess I am venting a little bit to release some frustrations.  Tomorrow is another day with new problems.  The key is to take one day at  a time, but how many of us really do that.  The support we give to one another on here is a real blessing, and I think thats how many of us get through it all.

            I am always here to listen to anyone else who wants to vent also.  We all need to do that once in awhile.

            • Re: According to this report we shouldn't be taking PPIs and certain other drugs with Gleevec...
              hannibellemo Registered Users
              Currently Being Moderated

              Susan,

               

              I understand what you mean about things, other than CML getting to you! I found that Yoga breathing and relaxation poses really helped. The breath is so important in controlling anxiety and panic. I can tell when I am only chest breathing and making myself breathe properly really helps. I have a deck of yoga cards that I use to mix it up. You can get them on amazon or any good bookstore.

               

              Right now about the only pose I can do is the sponge, but it's my favorite anyway! Lie on your back and starting from your toes contract and relax all the major muscle groups. Don't rush it! Then place both of your hand over your lower abdomen and breathe so your hands rise and fall with the breath. If you fall asleep during this mores the better.

               

              Pat

            • Re: According to this report we shouldn't be taking PPIs and certain other drugs with Gleevec...
              pamsouth Registered Users
              Currently Being Moderated

              Hi Susan,

              Susan61 wrote:

               

              Thanks Judy:  I try not to talk about things other than CML, but like I say we live with other problems as well.  Sometimes the other problems can make living with CML harder.  Just so everyone knows its not because of  my CML, its just struggling through with so many other things that I deal with on a daily basis.  Finances, insurance costs. I am trying to help out other family members with issues.  It just all piles up on me, and I guess thats how my body and mind handle it all.  I will suvive it, and I am very open to any suggestions.  I know I am not the only one who has or has had this problem.  It only started about 2 years ago, and I have had CML for 13.years. 

              My husband has had cutbacks on the job, just like  many others.  This has just been a real bad week for me.  My Arthritis has been brutal.  I have it all over, especially in my neck and back and legs.  So I guess I am venting a little bit to release some frustrations.  Tomorrow is another day with new problems.  The key is to take one day at  a time, but how many of us really do that.  The support we give to one another on here is a real blessing, and I think thats how many of us get through it all.

              I am always here to listen to anyone else who wants to vent also.  We all need to do that once in awhile.

              I know what you mean about the finances, insurance, and helping family member issues, I got the same thing. 

               

              I finally went to my new CML  Onc today at Indiana University.  The last time I was to my previous oncologist was in Oct 2011,  and Nov 2011 for a second consultation with my new CML Oncologist, at  Indiana University, he is an expert in CML!!.  My Blue Cross Ins. finally paid by Previous Onc for my visit back in Oct 2011..  However the appointment for November 2011 with new CML Onc at IU is still not paid and here it is Mar 19 2012.   last week I called Blue Cross insurance and they are going to reprocess the claim for the 4th time FOR IN UNIV..  It will take another 3 weeks, who knows, if it get turned down again, if so it will be because it was a consultation for a second opinion. Hopefully the office visit for today will get coded correctly and get paid the first time around.

               

              Got all my labs done today, (here at Ind Univ) they took 5 vial of blood.  Since this is my first time to get labs here at Indiana University and they also interpret their own labs, The ONC Dr. wants me to come back in a month.  We need to get a Guideline started here at IND UNIV.  At my previous oncologist the vials of blood were sent from here in Indiana to New Jersey.  (today) The new oncologist  was just saying he had another new patient with the same problem, sending the PCR blood labs out of state and the results are all over the place.  I hope I don't have to have a BMB again.  He said sometimes when the Fish and PCR are very different, (he gave me more details) sometimes you can have a new mutation.  So it just depends on how today's labs and  the 1 next month come out.  He is very smart, he is with the Leukemia Specialist group.  He knows so much more then my old onc., I can tell by the informatin he shares.  My other once says "zelch"  I am excited to be at the number 1 cancer center of Indiana.

               

              Next January I will be 65 years old Medicare age thank God, I won't have to worry about paying Doctor bills.   My husband is on Medicare his secondary Is Blue Cross of Micigan UAW retiree, and Medicare is so......... much better, even thought people complain about federal insurance.  I am counting down the months, weeks and days untill Medicare.  Actually I found out that if your birthday is Jan 1 you get to go back 1 month to Dec 1 to be on Medicare.

               

              I tried to do some wall painting in 1 of the bedroom and steaming some floors, Also went to a massage class and gave my neighbor a massage.  Now my hands are all swelled up got an appointment with the Chiropractor and Physical Therapy this after, then a real massage from a great lady.

               

              P.S My husband is retired electrician but  he working Part time as a greeter at Meijer,  It really helps us out as we had all these medical bills and was  helping are family.  We build a new house in 2007 and that was not so good ideal with the downfall of housing market.

               

              Got to run, PamSouth

            • Re: According to this report we shouldn't be taking PPIs and certain other drugs with Gleevec...
              Judy2 Registered Users
              Currently Being Moderated

              Hi Susan,

               

              I am glad you are venting about your issues, you are always there to help others and I'm hopeful others will be able to help you. Are you struggling to pay for your meds? If so, have you contacted the drug company? Have you taken advantage of the LLS grant. after all every little bit helps.  As far as talking about issues other then CML, we are more then just our CML and as you said sometimes the other issues can make living with CML harder. I think stress in our lives plays a big part in our medical health. Do you think your stress triggered your arthritic flair ? Susan, I know you always talk about how well you are doing, that you have had CML for 13 years, but how does dealing with 13 years of PCR tests, waiting for the results affect you? I've only been doing this since last spring and I have to think that 13 years of it would get extremely tiresome. I wish I had some answers for you, something profound to say. I guess what I can offer is my support, if you ever want to private message me I am here. I'm hoping tomorrow is a better day for  you.

               

              Hugs,

              Judy

              • Re: According to this report we shouldn't be taking PPIs and certain other drugs with Gleevec...
                Susan61 Registered Users
                Currently Being Moderated

                Hi Judy:  You made a good point regarding the anticipation of waiting for PCR tests.  Yes, no matter how good I have done on my Gleevec, and I count my blessings when I hear others horror stories About how they felt on Gleevec I still go through the stress until I get my call to say that I am still PCRU.  ITs because we have no idea what will happen as the years go by.  TKI drugs were a new invention, and basically a miracle for so many of us who did not get a BMT.

                We all would love to be able to see into the future as to what these drugs will do. 

                     I do  plan on contacting some drug companies regarding assistance.  Just today my  husband tells me he needs a refill on one of his meds.  I am glad that we have the mailorder plan through my husbands insurance, but its still too much money to lay out.  Through the mailorder his 90day supply is $130.00.  I called my  local phcy just to see what they would charge if I broke it up into 30 pills at a time. He said $245.00 for a 30 day supply, and that laying out the money for the 90days at once is saving me money in the long run.

                    Been trying to hold out a little bit, as my husband is trying to make some changes on the job to increase our income.  Like I said I have a lot on my plate, but again I thank everyone for all the help.

                    Right now my best friend invited me over for lunch to help me relax, so I will be back on later.

            • Re: According to this report we shouldn't be taking PPIs and certain other drugs with Gleevec...
              pamsouth Registered Users
              Currently Being Moderated

              Susan, Are you medicare yet?  I hears some people say that Medicare pays for massages.  That would maybe help your arthritis.

               

              PamSouth

              • Re: According to this report we shouldn't be taking PPIs and certain other drugs with Gleevec...
                Susan61 Registered Users
                Currently Being Moderated

                Hi Pam:  I am not on Medicare yet, and as long as my husband is carrying insurance on us I will not sign up for it due to having the extra money that would be taken out of my check each month to pay for the Medicare.

                I have heard a lot of problems people have had with Medicare where they have to come up with money for a certain period of time before it gets picked up again.  I am not explaining it properly, because I do not understand what they refer to as the Donut Hole. I just have to keep doing what I am doing for now.

                Hopefully my husband will be working for at least  another 6 years before he has to go on Medicare.  I am a little older than my husband.

            • Re: According to this report we shouldn't be taking PPIs and certain other drugs with Gleevec...
              pammartin Registered Users
              Currently Being Moderated

              Susan,

              You listen and support all of us constantly, please post whatever you are feeling, we might not be able to provide support in person, but we sure can load you up with posts.  You are awesome and you are always one of the first ones who welcome a newbie, let alone offer advice and your own personal experiences.  I deal with panic attacks also, they are horrible.  The Xanax does take care of them, but then I sleep for several hours even on half a dose.  I hate that.  Used to take up to 4 a day and it didn't effect me, now my tolerance must be low from the TKI so it hits me hard.  Please share whatever you wish, even if it is not CML.  We are here for you, just as you have always been for us.

              Take care

              Pam

              • Re: According to this report we shouldn't be taking PPIs and certain other drugs with Gleevec...
                Susan61 Registered Users
                Currently Being Moderated

                Hi:  I was on Zoloft when I was first diagnosed with CML, and I was not experiencing panic attacks back then it was just depression.  To some extent it did help me, but later on I felt nothing.  I could not even cry at a funeral for a family  member.  It was a horrible feeling.  I went off of it about 3 years ago I think, and have been fine until last year when all of this hit me.  I still think its all due to the struggling with everything just to survive these days, and everyone handles  their stress in different ways. 

                I got out for a few hours today, and it did make me feel better.  I have also been concerned about my right leg that I had a blood clot in back in Feb. of 2011. It just hurts all the time.  I wonder if thats normal. I do not know if anyone else on here has dealt with a DVT at some point. 

                • Re: According to this report we shouldn't be taking PPIs and certain other drugs with Gleevec...
                  GerryL Registered Users
                  Currently Being Moderated
                • Re: According to this report we shouldn't be taking PPIs and certain other drugs with Gleevec...
                  billronm@roadrunner.com Registered Users
                  Currently Being Moderated

                  Dear Susan,

                     I'm so sorry you're having such a bad time. I wish I lived closer,I'd give you a big hug. Instead i'm sending you a virtual extra big hug. You are so special, you're always right there welcoming a new member or comforting us when we need it. You have so much on your plate right now, cml, arthritis, financial problems, and I know you're always doing something for your family. No wonder you're having panic attacks. They are so terrible, i've suffered from them for years. If I feel one coming on I try to get up and do something, that very seldoms works,so I'll take a xanax and call somebody, usually my sister, if she's not home I'll call a friend. Just talking to someone for a few minutes helps me take my mind off of it. I take cymbalta as an anti-depressant, but it is also good for pain. I think that's why I don't have a lot of trouble with bone pain. I've been on it almost 5 years now, and I think it helps me quite a bit. It wouldn't hurt to ask your pcp about it. Try to put yourself first for a change and maybe you'll be able to handle your stress better. And you'll feel better.     Love Billie

                • Re: According to this report we shouldn't be taking PPIs and certain other drugs with Gleevec...
                  pamsouth Registered Users
                  Currently Being Moderated

                  HI Sweet Susie,  I have really appreciated your post, I mean that!

                   

                  Life can be unfair and sometimes sucks. From 1 cancer survivor to another, it seem like it lurks, sometimes outwardly, and sometimes hidden as though one forgets for a time. Praying for God to meet your needs spiritually, physically, mentally. I have had 5 intro to massage classes, actually I have had 2 clients I worked on, 1 was my neighbor, the other was a class mate. I am in the process of fixing up the front bedroom into a massage room, it is looking wonderfully serene. It help calm the soul, with beautiful pictures, flowers, candles, water fountain, an aromas.  My husband painted the walls with a warm butterscotch. Will go to the basement and look in some boxs, should have some lovely angels and things. My basement is full of hidden treasures. I am not certified yet, but I am hoping to do a few massage a week (not able to do many, my bones hurt) to raise money for cancer, and also to give free massages to cancer survivor or those with devastating illness.

                   

                  If we closer I would give you a massage anytime!!  I promise I will get better as time goes on, but I need some practice, so I am looking for bodies, ha!

                   

                  Take Care of Yourself!!

                  Hugs xoxo PamSouth

                  • Re: According to this report we shouldn't be taking PPIs and certain other drugs with Gleevec...
                    billronm@roadrunner.com Registered Users
                    Currently Being Moderated

                    Dear Pam,

                      You can have my body, nobody else wants it!  luv Billie

                    • Re: According to this report we shouldn't be taking PPIs and certain other drugs with Gleevec...
                      pamsouth Registered Users
                      Currently Being Moderated

                      My, My, My, Billie,  Whatever can I do for YOU. Yes, Yes You would love my Serenity Room.

                       

                      I like to call my massage room, the "Serenity Room."

                       

                      Come smell the lilacs and enjoy the flowers, music and low lights with bubbling fountains, a plants.

                      Smell the wonderful aroma of lilac, take a deep breath, very deep, all the way to the soul.  Breath out slowly all the bad, negative, stuff.  Fill your pretty little head with beautiful thought and go off somewhere peaceful! Give yourself a little indulgence, not suppose to have any whine, as you are suppose to drink water to remove the toxins, oh what the heck, maybe just a couple of oz,

                       

                      Bring your troubles and leave them when you go, Poof/gone! Sweet Dreams to leave with.

                       

                      Dance as though no one is watching, Love as though you have never loved before, sing as though no one can hear you, Live as though heaven is on earth.

                       

                      LIVE, LOVE, AND DON’T FORGET TO LAUGH.

                       

                      HUGGS TO ALL, I LOVE YOU MY SPECIAL ANGELS!!

                       

                      PAMSOUTH

                  • Re: According to this report we shouldn't be taking PPIs and certain other drugs with Gleevec...
                    Judy2 Registered Users
                    Currently Being Moderated

                    Hi Susan and Pam South,

                     

                    Susan, I sent you a private message.

                     

                    Pam South, please let us know how your blood work turns out, I'm praying all will be well and there will be no need for  you to change meds as I know that is something you do not want to do.

                     

                    Hugs to both,

                    Judy

                    • Re: According to this report we shouldn't be taking PPIs and certain other drugs with Gleevec...
                      pamsouth Registered Users
                      Currently Being Moderated

                      My Special Judy,  I sent you a reply and poof my pc went into outerspace and just returned.

                       

                      Not sure exactly what I said, no problem, my brain is still on a roll.

                       

                      Oh yes, Thanks for asking about my labs.  I am anxious to hear, whether it be good or bad.

                       

                      They took 5 vials of blood, as testing for other stuff, lets see; CBC, CMP, FISH, BCR/ABL, CYTOGENTICS, PCR FOR BCR/ABL.  I think he said the FISH AND PCR only look for BCR/ABL but he was going fishing looking for other things.  I think basically that is because I am his new patient, and he is enthralled with doing a good work up.  Yep he is one of those kind of doctors, very through.  He also said I don’t like switching around on these TKI unless there is a very good reason!!  Yep my kind doc!!  He is even trying to raise $50,000.00 for LLS, that's my DOC!!!  I am pretty happy to officially be a patient of one of the top #1 Cancer Center of Indiana University Simon Cancer Center.  I’m in the hands of 1 of Top CML Oncologist Expert of  Indiana, just 15 miles away.  interestedly enough he mention he just took on another patient complaining about some of the same things I was.  one is sending the PCR out of state, and results looking very inclusive and doc’s changing TKI at the drop of a hat. Now there was some of my paraphrasing or embellishing, a little.   He is pretty dog gone intelligent, so far, that is!  I will call in about a week and have them mail the results to me.  I have another appointment in a month for more test. Then the good doc will give me the verdict of what is going on and my choices.   Pretty cool, to feel I can rest now, even if it is not good news, at least I’m going to someone who knows his stuff, in fact I am sure if he was a good specialist he wouldn’t be at Ind University.  Maybe things worked out for the best, me and the old onc having that little tiff, or difference.   You know that little inner voice you hear sometimes, like you are wrestle with something and this inner voices keeps trying to say shut up and listen up, now!!  Well you got to listen to it, that voice is trying to tell you something. I just got to get in a place where I can hear, what my heart is saying.

                       

                      I don’t know why, but I feel good today!  Indiana went from winter to summer, it’s about 81 degrees out today.  it feels good to feel the sunshine and wind blowing thru my hair.  The kids are out playing.  When I walk by they yell for my poodle Mr Herchel, he is 20lb and looks like a young pup, he acutally 6 years.  You know like me  64 years going on 39, just a young chick.  Ahh to be young and deeply in love again.  Got a girl on my facebook who just got married, she is still up in heaven. I told her to stay up there as long as she can........

                      She is still pinching herself MRS.... 

                       

                      Got my Seniority Room almost done, got to wait up to 10 days to get my throw carpet in, got hardwood floors, so didn’t want to totally cover them up. Actually my secret is this,  I am taking “Intro to Swedish Massage Class, to teach my husband how to give me massage, pretty cool huh.  Yea I got him going pretty good on those shoulder blades.  You know you just lay face down, fold a towel put it under your shoulder, then have him take two or three finger in a friction circular motion go up the shoulder blade, until he comes to a knot, then just do the circular friction motion, until I tell him to stop, oh yea and just the right pressure.  He is pretty good.  Problem is he get tired, before I tell him to stop! 

                       

                      It is after midnight got to get my beauty rest. Another sunny day tomorrow!  Tomorrow I am going to my chiropractor nd they give me TLC!  Yes they do, cause I got them trained too!!

                       

                      Oh, I got another plan, too.  Like I learn how to do massage then I use it for barter.  Like a need a cleaning lady, and a sewing lady, etc.  You get the picture.

                       

                      Sending hugs xoxo

                      PamSouth

  • Re: According to this report we shouldn't be taking PPIs and certain other drugs with Gleevec...
    Sneezy12 Registered Users
    Currently Being Moderated

    The operative words in the article, are "could" and "may". There are no peer-reviewed scientific articles indicating that Gleevec reacts adversely with Omeprazole or Ciprofloxin. Frank   However, all 3 can cause Liver Toxicity. Frank

     

    Message was edited by: Francis Farrell

  • Re: According to this report we shouldn't be taking PPIs and certain other drugs with Gleevec...
    billronm@roadrunner.com Registered Users
    Currently Being Moderated

    Hi Pat,

       I just remembered the name of that antibiotic, it's called Cipro.  Now if I can just remember all the things I'm supposed to remember I'll be in good shape.

                                                                                                                                Billie                                                   

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