The Leukemia & Lymphoma Society - Fighting Blood Cancers
4 Replies Latest reply: Oct 21, 2011 10:30 AM by tburkhardt RSS

HDMTX

balkan123 Registered Users
Currently Being Moderated

We have 4 doses of HDMTX 5 gm/sqmtr in 2 months.......after induction....

The first  doses started 4 days back..........We are inpatient...

42 hrs after MTX  level was 1.58 umol/l , at hour 48 0.87umol/L ,at hour 60 .57umol/L,at hour 66 0.39umol/L...

Onc wants it to come to .25umol/L before we can head home......

My son is restless to hilt ......wants to leave hospital.....

As such no effects of HDMTX till now.....

Why this Mtx level is so slow.....

At what level they leave you....

What issues we expect in coming few days

  • Re: HDMTX
    tburkhardt Registered Users
    Currently Being Moderated

    Be patient  - I know it's hard.  We had to wait for levels to be below 0.1 before we could leave.  If mtx continues to hover, I would ask about delayed clearance procedures.  They may up the leucovorin to every 3-4 hours.  Also watch for any neurotoxicity, kidney toxicity, mucositis, and stay out of light/sunlight if you can.  

    • Re: HDMTX
      balkan123 Registered Users
      Currently Being Moderated

      Thanks Tonya....We were let of on hr 82 with level .24 umol/L

      What the others have experienced ...till what level clearance they observe...to save kidney toxicity...

      • Re: HDMTX
        leann's_mom Registered Users
        Currently Being Moderated

        That's interesting that they let you out at a level above .1. We have to wait until her MTX level hits .1 or less. For her first round (started 4/4), she cleared at the 72 hour mark with a .07 level. She did not have any mouth sores, but had a rough time with nausea/vomiting from day 2-4 post infusion. Her counts took a deep hit, falling from an ANC of 987 at admit, to 894 at discharge, to an 280 ANC last Tuesday.

         

        However, her counts rebounded with an ANC of 763, so she's gotten her VCR dose and we've been admitted to start hydration for this second round.

         

        Good luck.

         

        -Karen

  • Re: HDMTX
    tburkhardt Registered Users
    Currently Being Moderated

    Bump for abslater.  

More Like This

  • Retrieving data ...